Evaluation of Alpha-Thalassemia Mutations in Cases with Hypochromic Microcytic Anemia: The İstanbul Perspective
نویسندگان
چکیده
منابع مشابه
Evaluation of Alpha-Thalassemia Mutations in Cases with Hypochromic Microcytic Anemia: The İstanbul Perspective
OBJECTIVE Alpha thalassemia syndromes are caused by mutations on one or more of the four α-globin genes. Mutations could be either more commonly deletional or non-deletional. As some deletions (3.7 and 4.2) cause α+-thalassemia, some cause (-20.5, MED, THAI, FIL) α0 -thalassemia. The aim of this study was to determine alpha thalassemia mutations in patients with unsolved hypochromic microcytic ...
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BACKGROUND Microcytic hypochromic anemia is a common condition in clinical practice, and alpha-thalassemia has to be considered as a differential diagnosis. AIMS This study was conducted to evaluate the frequency of alpha-gene, beta-gene and hemoglobin variant numbers in subjects with microcytic hypochromic anemia. SETTING AND DESIGNS Population-based case-control study in the Iranian popul...
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Most common microcytic hypochromic anemias are iron deficiency anemia (IDA) and β-thalassemia trait (BTT), in which oxidative stress (OxS) has an essential role. Catalase causes detoxification of H2O2 in cells, and it is an indispensable antioxidant enzyme. The study was designed to measure erythrocyte catalase activity (ECAT) in patients with IDA (10) or BTT (21), to relate it with thalassemia...
متن کاملHereditary hypochromic microcytic anemia in the laboratory rat.
The group of 17 irradiated rats including the animal that produced anemic progeny (X2) belonged to a stock of rats randomly bred in our laboratory since 1930. The X2 female was one of five females in a litter, which were X-irradiated under conditions reported earlier (SLADICSIMIC et al. 1963). All irradiated females were mated with normal males from the stock and brother-sister matings for each...
متن کاملmolecular analysis of alpha globin gene deletions among patients with microcytic hypochromic anemia in kermanshah-iran
background: the majority of α-thalassemi mutations are deletions of one or both α-globin genes. since the iranian populaion is a mixture of different ethnic groups, frequency and distribution of globin mutations in various regions of the country need to be clarified. the aim of this study was to determine the common alpha globin gene deletions among individuals with hypochromic microcytic anemi...
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ژورنال
عنوان ژورنال: Turkish Journal of Hematology
سال: 2015
ISSN: 1300-7777
DOI: 10.4274/tjh.2014.0204